Everyone has different thoughts and opinions on this. I personally have never shied away from a new specialty. I am not saying I promote learn as you go but I do believe if you are a good biller and the information given to you is clean you can do a good job even with a specialty you are unfamiliar with. I do believe you should do anything you can to familiarize yourself with the specialty. Not all information given is clean and a good biller picks up on mistakes before submitting the claims whenever possible. I haven't done oncology specifically so I can't give you any pointers, but I'm hoping someone else on the forum may be able to help you out.