We have used Lytec since 1994. Definitely has both pros and cons but overall I am happy with it. I am familiar with Medisoft and I don't really care for it. To me the Lytec is much more user friendly and has more capabilities. Personally I have always been able to get the Lytec to do whatever we needed it to do. I find it easy to train others on how to use it. It doesn't have as many bells and whistles as some more complex programs, but as a biller, I don't need all of those.
Hope that helps.