I recently had this happen with a doctor. He insisted I bill certain PQRS codes on his claims, although I knew they would not be accepted by Medicare and some Medicare Advantage plans through Aetna and UHC. Lo and behold, all the claims denied in full because of the PQRS codes. Luckily, I only put about ten through to prove my point to him. So while I cannot answer your question definitively, I can say from my experience that the whole claim denied for one invalid line on each claim.